Antibiotic resistance has been one of the main negative reasons for obstructing antibiotic entrance into the human body. This has become the reason for a huge number of illnesses and deaths worldwide. The study has focused on reviewing an article that concerns the topic of Ecological features influencing the progress and expansion of antibiotic resistance. The paper has reviewed a research article that several researchers on the development of antibiotic-resistant genes have executed. The study's main aim is to investigate the microbes that resist the antibiotic to combat the harmful bacteria responsible for resisting antibiotics to fight against harmful bacteria