ROLE OF MATRIX METALLOPROTEINASE -9 (MMP -9) CONCENTRATION IN THE PATHOGENESIS OF PREECLAMPSIA

Background: Preeclampsia is a syndrome related to pregnancy and represented the second common maternal and infant death causes. The metalloproteinase is involved in vascular growth of placenta, and it has been shown to have a role in preeclampsia pathogenesis. Aim of study: The evaluation of metalloproteinase role in prediction of pre-eclampsia in pregnancy. Patients and methods: This is acase control study conductedatObstetric & Gynecological Department of Al-Daquq general hospital in Kirkuk during the period from 1st of March to end of November 2017.A sample of 50 preeclamptic pregnant women, 25 preeclamptic pregnant females of gestational age of (< 37 weeks) and 25 preeclamptic pregnant women with gestational age of (more than 37 weeks) were included in the study. A sample of 50 healthy controls, 25 healthy pregnant women with gestational age of (<37 weeks) and 25 healthy pregnant females with gestational age of (more than 37 weeks). Results: In contrast to preterm controls, there was a highly important correlation between lower mean Metalloproteinase-9 and pregnant preterm women with preeclampsia (p<0.001). In contrast to term controls, a highly significant correlation was observed between lower mean Metalloproteinase-9 and term pregnant women with PE (p<0.001). In pre-eclampsia prediction, Metalloproteinase-9 levels of 26.2 for pre-term and 34.4 for term were cut off. Conclusions: The matrix metalloproteinase 9 is a non specific predictor of preeclampsia for term and preterm pregnant women but with higher accuracy for preterm pregnant women.