The digestion tube is a natural microorganism. The intestine is free of bacteria at birth, but it quickly becomes a host for numerous bacteria and regularly establishes a mutual relationship. Irritable bowel syndrome (IBS) is a common and sometimes chronic weakness of gastrointestinal function. Symptoms of irritable bowel syndrome include abdominal pain and altered bowel motility. The aetiology of this syndrome is likely to be heterogeneous. Moreover, it is measured as a disease of instinctive-intelligence interaction; then, the microbiome is often implicated as a central player in the pathophysiology of irritable bowel syndrome through patients showing alterations in the configuration and purpose of the gut microbiota associated with healthy controls. Enterobacteriaceae faecal are observed in increased numbers of patients with irritable bowel syndrome. The presence of Escherichia coli strains in the lower intestine of humans may comprise numerous possibly pathogenic adhesive path types. The aim of this review is to summarise the available works on the microbiome influence on the pathophysiology and symptoms performance of IBS, in addition to the present results on microbiome-beleaguered demeanours aimed at this illness.